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Contrave Vs Phen375

Phen375 Vs Contrave – Is FDA Approval Enough?

In the spirit of successful drugs like Phentermine, which was removed from the market back in 1996. A huge flow of pharmaceutical producers decided to act by providing another prescribed weight-loss drug to take the lead of Phentermine. The FDA has not approved a new weight loss medication in ten years. However, It seems Orexigen Therapeutics (Contrave producers) fought a big war to earn that FDA approval for the Contrave weight loss pill.

However, Contrave warning labels caution patients to be aware of suicidal thoughts while encouraging emergency medical attention! What are we dealing with? What is Contrave? Is it right for you? How does it work? Is there a Contrave safe alternative? These question will be answered later in this research but first, we would like to run a brief comparison between Phen375 and Contrave.

As Phen375 is one of the leading top selling weight loss pill taking it as a reference will provide clear points to compare from.

Phen375 Vs Contrave (User Reviews)





Clinical Studies


  •  Increase metabolic rate based on its thermogenesis effect leading to more energy.
  • Weight loss rate from 3-5 lbs per week.
  • Anti-depressant effect to avoid any depression during weight loss journey.
  • Appetite suppression; avoid food craving


  • Promote weight loss by affecting the appetite chemicals in the brain.
  • Act on impulse, reward, and/or hunger centers in the brain to decrease appetite and dampen the reflex to seek food for comfort.
Side effects


prosNone; rare mild headaches Worst-fatburner-reviewscan cause serious side effects

  • nausea and vomiting
  • constipation
  • headache
  • dizziness
  • insomnia
  • dry mouth
  • diarrhea
  • elevated blood pressure and heart rate
  • seizures


Best uses prosBodybuilding, Energy Boost, Maintaining weight, Weight loss prosAppetite suppression, weight loss
Money back guarantee


pros30 days Worst-fatburner-reviewsNo money back guarantee
Appetite suppressant prosYes prosYes
Anti-depressant prosYes prosYes
Weight loss effect pros3-5 lbs per week (depending on your daily activity and food consumption) Worst-fatburner-reviewsNo evidence for weight loss… the results highly vary… (You can Understand why through reading the rest of this research.)
Reorder rate  prosHigh prosMedium


 prosNo Prescription – It can be purchased online from the official website Worst-fatburner-reviewsPrescription required – It can’t be purchased online and can only be prescribed through your doctor.
User reviews


 prosExcellent – Check out what users say on Phen375 Worst-fatburner-reviewsModerate – most Contrave users agree about the massive side effects they get from Contrave –  this point affected the overall user ratings massively.
Production Company details prosRDK Global, they are the manufacturer and distributor of top selling weight loss and pain relief natural supplements. All their products are manufactured in FDA-approved laboratories in the United States and the European Union. prosOrexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. Currently based in California in the USA.
Price  $65.95 – per bottle (they offer free bottle on 3 bottle order) check their offers on the official site. $200 – per bottle
Order Now


 Official Website-

Official website –

Contrave User Reviews – Is FDA Approval Enough?

Contrave is a combination of two FDA approved drugs, bupropion and naltrexone. The bupropion (Wellbutrin), is an antidepressant. While the naltrexone, is an anti-addiction drug. The combination is expected to have a synergistic effect in aiding weight loss.

Ingredients and How It works?

Dr. Jennifer Ashton explains how the new drug works

Ingredients are; 8 mg naltrexone HCl /90 mg bupropion HCl

Naltrexone has been used in the United States to treat opioid addiction since 1984. This drug inhibits the reinforcement of addictive substances by blocking opioid receptors to the brain. Bupropion has been used to treat depression. How the combination works for weight loss is not entirely understood, even by experts. The bupropion helps lessen appetite, says William Troy Donahoo, MD, an endocrinologist and weight loss specialist at Kaiser Permanente, Denver. The naltrexone, he says, probably works by blocking certain receptors in the brain and curbing cravings.

Does Contrave have side effects?

Contrave_side effectsBupropion has caused some people to have suicidal thoughts or actions or unusual changes in behavior, whether or not they are taking medicines used to treat depression. Bupropion may increase suicidal thoughts or actions in some children, teenagers, and young adults within the first few months of treatment.

Contrave is not for anyone who has:

  • Have uncontrolled high blood pressure
  • Have or have had seizures
  • Use other medicines that contain bupropion such as WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL,
  • Eating disorder
  • A narcotic addiction or who is taking medication to treat one.

Does Contrave work?

The amount varies, but on average, people lose 5% to 10% of their starting weight, according to clinical trials and experts.

In one 56-week study looking at Contrave combined with health habit changes, those on the drug lost more than 9% of their starting weight, while those on placebo lost just 5%.

So a 200-pound person losing 10% would end up at 180 pounds, perhaps moving from the obese to the overweight range, or the overweight to the healthy weight range.

If Contrave does not work after 12 weeks, the FDA says its use should be stopped.If a patient has not lost at least 5 percent of baseline body weight, Contrave should be discontinued, as it is unlikely that the patient will achieve and sustain clinically meaningful weight loss with continued treatment.

Main disadvantages of Contrave

  1. Has serious side effects.
  2. Only helps users to lose 5% of body weight in 14 months (you should lose more than that on your own).
  3. Cause seizures and heart attacks.
  4. Prescription required

How do you get a Contrave prescription?

Your doctor writes a prescription for it. But, to take advantage of the lowest cost available to you, there are certain pharmacies that will mail Contrave to you at a discounted price. The website will help you with this after you enroll in the savings program. It takes 2-3 weeks to get Contrave in the mail.

CONTRAVE dose escalation schedule (2.1):
Dose Morning Dose Evening Dose
Week 1 1 tablet None
Week 2 1 tablet 1 tablet
Week 3 2 tablets 1 tablet
Week 4 and Onward 2 tablets 2 tablets

Do not take CONTRAVE with high-fat meals. It may increase your risk of seizures.

Contrave Customer Reviews – From All over the web (click to enlarge )

Customers From



Customers From



Customers from personal blogs and facebook



Bottom Line

There’s no weight-loss cure that eliminates the need for diet and fitness— and it is important to stress that any weight loss pill must be paired with healthy behavior. Phen375 proved for the last 6 years that it had change lives through its fat burning mechanism. There is clear evidence of how it affects the metabolic rate. You can check Phen375 official site and also dig deeper with our user reviews on Phen375. The story with Contrave is still new and we did as much as possible to provide user reviews. We prefer safety over health risk and even if Contrave has powerful weight loss effect it is still unsafe along with its highly addictive ingredients.

Always go for slow Progress, but steady. You will likely get impatient, but more the dedication in exercise and a healthy diet along with a safe diet pill will certainly change your lifestyle to a whole new level.

About the author

Adam is a writer, healthcare professional, and he is always active in sharing recent case studies and breaking the mental and physical limits. He dedicated his life to transforming the lives of the skinny, out of shape, scrawny wimpy guys & skinny girls - helping them become healthier, fitter and more confident in their bodies.
2 Responses
  1. Leela

    Contrave was working , took it for 4 months, i saw how my appetite suppressed and my coffee addiction stopped I am a coffee drinker want it need it..but after a month I didn’t crave it. Or had a taste for it, I was noticing my waste line was slimming dwn, but I never reached my goal.

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